陳啟煌醫師的學經歷更新

台北醫學大學臨床醫學研究所博士 (MD,PhD),2012


美國Johns Hopkins University生殖內分泌不孕症臨床研究員

2002



美國Northwestern University試管嬰兒及人工生殖臨床研究員

2001-2002 (與師父張興琪Zhang, X教授)合影。



中華民國駐查德共和國醫療團團長 1999-2000

 

 

學歷

 

 國防醫學院醫學系畢業(M85期)

 

台北醫學大學臨床醫學研究所醫學博士

 

現職

 

 台北醫學大學醫學系專任部定副教授(副字第140823號)

 2015~迄今

台北醫學大學附設醫院婦產部暨

 生殖醫學中心不孕症科主任

人工生殖合格施術醫師

 

 

 

經歷

 

 中華民國駐查德共和國醫療團團長

 

美國Northwestern University試管嬰兒及人工生殖臨床研究員

 

美國Johns Hopkins University生殖內分泌不孕症臨床研究員

 

台北醫學大學附設醫院生殖醫學中心臨床研究員

                                                     

 

門診時刻表

第三醫療大樓二樓婦產科門診 

 *第三醫療大樓二樓婦產科為不孕症一般門診

(初診一律在此,五樓生殖中心不接受出診)

 (網路可掛號,不限號)

 

 第三醫療大樓五樓生殖醫學中心(限特約

        特約專線: 27372181 ext 8540

       專長試管嬰兒、冷凍胚胎、人工受

       精、不孕症及腹腔鏡子宮鏡手術

 

 

 

 

主治專長:  

 

試管嬰兒、冷凍胚胎及配子、人工受精、不孕症、

 

生殖保存(癌患)、腹腔鏡手術

 

 專科証書:

 

• 醫師證書(醫字第021969)

 

• 考試院專技醫師高考檢覆及格證書(台檢醫字第25188)

 

• 婦產科專科醫師證書(婦專醫字第002246)

 

• 人工生殖合格施術醫師

 

 

學會

 

• 台灣婦產科醫學會會員

 

• 周產期醫學會會員

 

• 台灣生殖醫學會會員(台生證91字第225)

 

• 美國生殖醫學會會員(ASRM)

 

• 歐洲生殖醫學會會員(ESHRE)

 

• 歐洲內分泌醫學會會員(ECE)

 

 

國科會研究計劃主持人陳啟煌

 

• 九十二年國科會研究計劃

 

「兔子卵巢的冷凍保存及移植」(92-2314-B-016-078-)

 

主持人

 

• 九十三年國科會研究計劃

 

「精索靜脈曲張對精蟲品質及細胞凋零的影響」(93-2314-B-016-037-)主持人

 

• 九十六年度國科會研究計劃

 

「研究有效的性腺冷凍保存與移植的方法及冷凍傷害機轉的動物模式」主持人 (96-2314-B-016-023-)

 

• 九十七年度國科會研究計畫

 

「以基因轉殖鼠冷光表現活體追蹤生殖保存與延續的動物模式」(NSC 97-2314-B-016 -012 -MY2)-2年主持人

 

• 九十七年度國科會研究計畫

 

「增進自體脂肪移植存活的研究基因轉殖鼠冷光活體動物實驗」共同主持人

 

• 九十九年度~一百零二年度國科會研究計畫

 

「移植冷凍保存的精原幹細胞以重建精子形成小鼠生殖保存基因轉殖模式 (NSC- 99-2314-B-016-013-MY3)-3年主持人

 

• 一百零二年~一百零三度國科會研究計畫

 

以組織工程再生保存未成熟雄性睾丸的生殖能力 - 基因轉殖鼠模式

NSC 102-2314-B-038 -045 -主持人

民國103年~105年度國科會轉譯醫學研究計畫主持人

「以基因轉殖冷光小鼠模式研究組織支架於卵巢移植之應用」

MOST 103-2321-B-038 -008 -

MOST 104-2321-B-038 -002 -

 

科技部專題研究計畫: MOST 106-2314-B-038-076 (106.08.01~107.07.31)

以奈米支架提升小鼠移植未成熟冷凍睪丸組織之存活率 - 基轉小鼠模式

 

學術會議
A. Congress: 20th World Congress of The International Federation of Fertility Societies (IFFS)
Dates: 2010/09/12-16 Place: Munich, Germany Funding: NSC-97-2314-B-016-012-MY2
Subject: Tracking the effects of immunosuppression by in vivo bioluminescence imaging after allotransplantation of
ovarian grafts.
B. Congress: Fertilink and International Ovarian Conference (IOC)
Dates: 2010/10/16-17 Place: Kyoto, Japan Funding: NSC-97-2314-B-016-012-MY2
Subject: Protective effect of a gonadotropin-releasing hormone analogue on chemotherapeutic agent-induced ovarian
gonadotoxicity: A mouse model. (優秀論文獎)
C. Congress: Taiwanese Society for Reproductive Medicine Annual Meeting (TSRM)
Dates: 2011/08/27-28 Place: Taiwan, Tainan Funding: NSC-99-2314-B-016-013-MY3
Subject: Protective effect of sphingosine 1-phosphate (S1P) on chemotherapeutic agent-induced ovarian gonadotoxicity.
(優秀論文獎)
D. Congress: American Society for Reproductive Medicine 67th Annual Meeting (ASRM)
Dates: 2011/10/15-19 Place: Orlando, Florida Funding: NSC-99-2314-B-016-013-MY3
Subject: Bioluminescence imaging (BLI) as a tool to evaluate germ cell in vitro and transplantation in vivo as fertility
preservation of prepubertal male mice.
E. Congress: The international Ovarian Conference (IOC)
Dates: 2012/03/17 Place: Tokyo, Japan Funding: NSC-99-2314-B-016-013-MY3
Subject: Tracking the development potential and the onset inhibition of primordial follicle of the cryopreserved murine
ovary with bioluminescent imaging (BLI) in vivo. (優秀論文獎)
F. Congress: Controversies in Cryopreservation of Reproductive cells, Tissue and Organs (CRYO)
Dates: 2013/03/21-23 Place: Berlin, Germany Funding: NSC-99-2314-B-016-013-MY3
Subject: Antiapoptotic agent sphingosine-l-phosphate(SlP) protects against ischemic reperfusion injury of vitrified murine
ovarian grafts
G. Congress: American Society for Reproductive Medicine 69th Annual Meeting (ASRM)
Dates: 2013/10/12-17 Place: Boston, USA Funding: NSC-102-2314-B-038-045
Subject: In vivo immature testicular tissue engineering for male fertility preservation - a transgenic mouse model.
(海報類第一名)
H. Congress: European Society of Human Reproduction and Embryology (ESHRE)
Dates: 2014/06/29-07/02 Place: Munich, Germany Funding: NSC-102-2314-B-038-045
Subject: In vivo optical imaging of immature mouse testicular tissue engineering by three-dimensional scaffolds for
pre-pubertal male fertility preservation

I. Ovarian transplantation with scaffold for drug delivery-an in vivo transgenic

mouse model. American Society of Reproductive Medicine 71th annual meeting. 海報

論文第二名, Baltimore, USA, 2015

學術著作
First and Correspondence
1. Chen CH, Chen SG, Wu GJ, Wang J, Yu CP, Liu JY. Autologous heterotopic transplantation of intact rabbit ovary after
cryopreservation at -196℃. Fertil Steril 2006 Oct; 86 (3):1059-66. Impact factor: 4.803 
2. Chen CH, Chen IC, Wang YC, Liu JY, Wu GJ, Tzeng CR. Boy born after gender preselection following successive
gestational androgen excess of maternal luteoma and female disorders of sex development Fertil Steril 2009 Jun;
91(6):2732.e5-7. Epub 2008 Dec 24 Impact factor: 4.803
First author
3. Chen CH, Huang YH, Lai WF, Wang CW, Hsu MI, Tzeng CR. Bioluminescence imaging (BLI) as a tool to evaluate germ
cell in vitro and transplantation in vivo as fertility preservation of prepubertal male mice. Fertility Sterility 2012 May; 97
(1) : 192-8. Impact factor: 4.803
4. Chen CH, Zhang X, Confino E, Milad M, Kazer RR. Relationships between peak serum estradiol levels and treatment
outcome in in vitro fertilization cycles following embryo transfer on day 3 or day 5. Fertil Steril 2003; 80:75-9. Impact
factor: 4.803
5. Chen CH, Huang RL, Yu MS, Wong LJC, Chao TF, and Chu TY. Hereditary nonpolyposis colorectal cancer with
gynecologic malignancies: report two families in Taiwan. J Formos Med Assoc 2001; 100:269-73. Impact factor: 1.695
(38%)
6. Chen CH, Lee SS, Chen DC, Chien HH, Chen IC, Chu YN, Liu JY, Chen WH, Wu GJ. Apoptosis and kinematics of
ejaculated spermatozoa in patients with varicocele. J Androl. 2004 May-Jun; 25(3):348-53. Impact factor: 1.694 (57.1%)
7. Chen CH, Yeh YC, Wu GJ, Huang YH, Thomas Lai WF, Liu JY, Tzeng CR. Tracking the rejection and survival of mouse
ovarian iso- and allografts in vivo with bioluminescent imaging. Reproduction 2010; 140: 105-112. Impact factor: 3.262
(23.3%)
8. Chen CH, Tan SJ, Tzeng CR. In vivo fate mapping of cryopreserved murine ovarian grafts. J Ovarian Res. 2014 Aug;7:81-7.
Impact factor: 2.030 (56.7%)
9. Chen CH, Tzeng CR. Ovarian tissue transplantation: current state and research advancement. Curr Obstet Gynecol Rep.
2013 Dec;2(4):202-210. (Review article)
Correspondence
10. Tan SJ, Yeh YC, Shang WJ, Wu GJ, Liu JY, Chen CH. Protective effect of a gonadotropin-releasing hormone analogue on
chemotherapeutic agentinduced ovarian gonadotoxicity: A mouse model. Eur J Obstet Gynecol Reprod Biol 2010; 149:
182–185 Impact factor: 1.627 (57.7%)
11. Lin CK, Chang WH, Pan HH, Chen CH. Postpartum hellp syndrome with unusually high levels of liver enzymes. Taiwan J
Obstet Gynecol 2009 Sep; 48(3) Impact factor: 1.261 (73.1%)
12. Chen DC, Chen CH, Liu JY, Ku CH, Wu GJ. Serum vascular endothelial growth factor165 levels and uterine fibroid
volume. Acta Obstet Gynecol Scan 2005; 84(4):317-21. Impact factor: 1.985 (39.7%)
13. Su HY, Chen CH, Gao HW, Liu JY. A bicornuate uterus with a unilateral cornual adenomyosis. Obstet gynecol 2005 May;
105(5):1191-3. Impact factor: 4.368 (3.8%)
14. Wang YC, Su HY, Liu JY, Chang FW, Chen CH. Maternal and female fetal virilization caused by pregnancy luteomas.
Fertil Steril 2005 Aug;84(2):509 (SCI) Impact factor: 4.295 (5.1%)
15. Su HY, Liu HY, Chen CH. Pelvic inflammatory disease combined with perforated peptic ulcer -mimicking tubo-ovarian
abscess. Int J Gynaecol Obstet. 2005 Mar; 88(3):329-30. Impact factor: 1.563 (64.1%)
16. Su HY, Chen WH, Chen CH. Extra-pelvic endometriosis presenting as a vulvar mass in a teenage girl. Int J Gynaecol
Obstet. 2004 Dec; 87(3):252-3. Impact factor: 1.563 (64.1%)
17. Chang FW, Yu MH, Wu CC, Chen WH, Chen CH. Cornual pregnancy treated with dilatation and curettage under
laparoscopic guidance- a report of two cases. Taiwanese J Obstet Gynecol. 2004; 43(4):229-231. Impact factor: 1.261
(73.1%)
18. Wu CJ, Peng YJ, Yu MH, Chen CH*. Secretory adenocarcinoma of endometrium in a postmenopausal patient with breast
cancer using tamoxifen. Taiwanese J Obstet Gynecol 2007 Mar; 46( 1). Impact factor: 1.261 (73.1%)
19. Chang WH and Chen CH. Unilateral obstructive uropathy caused by deep infiltrating endometriosis. J Med Sci 2008;
28(2):99-102.
20. Chang WH, Lin CK, Chiang YJ, Chen CH. Puerperal hematoma combined with retroperitoneal dissection & obstructive
uropathy. J Med Sci 2008; 28(2): 81-84.
21. Chang WH, Liu JY, Yeh YC, Wu GJ, Chiang YJ, Yu MH, Chen CH*. Tubal ligation via colpotomy or laparoscopy: a
retrospective comparative study. Arch Gynecol Obstet. 2011; 283:805-808 Impact factor: 1.279 (71.8%)
22. Lin YH, Chang FW, Chen CH . Perimenopausal amenorrhea with cervical atresia and hematotrachelos. Journal of Medical
Sciences 2010 Aug; 30(4).
23. Lin YS, Yeh YC, Tzeng CR, Shang WJ, Wu GJ, Liu JY and Chen CH. Evaluating the effects of immunosuppression by in
vivo bioluminescence imaging after allo-transplantation of ovarian grafts. Reproductive Biomedical Online 2010;
22:220-227. Impact factor: 2.980 (15.4%),
RBM online年度最佳論文第二名


24. Tsai YC, Tzeng CR, Wang CW, Hsu MI, Tan SJ, Chen CH. Antiapoptotic agent sphingosine-1-phosphate protects vitrified
murine ovarian grafts. Reprod Sci. 2014 Feb;21(2):236-43. Impact factor 2.179 (33.3%)
25. Tan SJ, Lee LJ, Tzeng CR, Wang CW, Hsu MI, Chen CH. Targeted anti-apoptosis activity for ovarian protection against
chemotherapy-induced ovarian gonadotoxicity.Reprod Biomed Online. 2014 Nov;29(5):612-20. Impact factor: 2.980
(15.4%)
Co-author
26. Zhang X, Chen CH, Confino E, Barnes R, Milad M, Kazer RR. Increasing endometrial thickness is associated with
improved treatment outcome for selected patients undergoing in vitro fertilization-embryo transfer. Fertil Steril 2005;
83:336-40. Impact factor: 4.803
27. Wang YC, Chen CH, Su HY, Li HS, Liu Y. Huge spindle cell hemangioma of the cervix-mimicking a pelvic tumor.
Gynecol Obstet Invest 2005 April 27; 60(2):98-101. Impact factor: 1.251 (74.4%)
28. 26. Wang YC, Liu JJ, Chen CH, Peng YJ, Yu MH. Peritoneal tuberculosis mimicking ovarian cancer can be diagnosed by
polymerase chain reaction: a case report. Gynecol Oncol 2005 Jun; 97(3):961-963 Impact factor: 3.687 (9.0%)
29. Chen DC, Chen CH, Su HY, Yu CP, Chen WH, Yu MH. Retroperitoneal lymphangiomyomas presenting as a pelvic mass.
Acta Obstet Gynecol Scand 2005 Sep; 84(9):917-20. Impact factor: 1.985 (39.7%)
30. Chang WH, Chen CH, Yu MS. Conservative therapy of stage I endometrial adenocarcinoma and atypical endometrial
hyperplasia for the preservation of fertility. Int J Gynaecol Obstet. 2006; 92(2):137-8 Impact factor: 1.563 (64.1%)
31. Wang YC, Chen CH, Su HY, Yu MH. The impact of maternal cardioversion on fetal haemodynamics European Journal of
Obstetrics & Gynecology and Reproductive Biology 2006 Jun 1; 126(2):268-274. Impact factor: 1.627 (57.7%)
32. Chen DC, Ku CH, Huang YC, Chen CH, Wu GJ. Urinary nitric oxide metabolite changes in spontaneous and induced onset
active labor. Acta Obstet Gynecol Scand. 2004 Jul; 83(7):641-6. Impact factor: 1.985 (39.7%)
33. Chen DC, Chen CH, Su HY, Yu CP, Chen WH, Chu TY. Huge pedunculated fibroma of the vulva. Acta Obstet Gynecol
Scand 2004; 83:1091-2. Impact factor: 1.985 (39.7%)
34. Chang FW, Chen CH, Liu JY. Early diagnosis of ovarian pregnancy by ultrasound. Int J Gynaecol Obstet. 2004 May;
85(2):186-187. Impact factor: 1.563 (64.1%)
35. Huang HC, Chen CH, Chu CC, Yu CP, Chu TY. Mature cystic teratoma of ovary with gliomatosis peritonei. J Med Sci
2004; 24(6):343-346.
36. Chang FW, Yu MH, Ku CH, Chen CH, Wu GJ, Liu JY. Effect of uterotonics on intra-operative blood loss during
laparoscopy-assisted vaginal hysterectomy: a randomised controlled trial. BJOG 2006 Jan; 113(1):47-52. Impact factor:
3.862 (7.7%)
37. Ding DC, Huang RL, Chen CH, Chao CF, Chu TY. Novel germline and somatic mutations of the MSH2 gene in hereditary
non-polyposis colorectal cancer. Clin Genet 2007; 71: 190–192. Impact factor: 3.652 (29.9%)
38. Wu GJ, Chang FW, Lee SS, Cheng YY, Chen CH, Chen IC. Apoptosis-related phenotype of ejaculated spermatozoa in
patients with varicocele. Fertility Sterility 2009 Mar; 91(3):831-837. Impact factor: 4.295 (5.1%)
39. Liu YL, Chen CH, Liu JY, Chang FW, Chen IC, Chien HH, Wu GJ. Influence of late follicular luteinizing hormone
concentrations on ovarian response and fertilization outcome in patients undergoing in vitro fertilization with a short
protocol. J Med Sci 2009; 29(4):195-198.
40. Chen HC, Sytwu JK, Chang JL, Wang HW, Chen HK, Kang BH, Liu DW, Chen CH, Chao TT, Wang CH. Hypoxia
enhances the stemness markers of cochlear stem/progenitor cells and expands sphere formation through activation of
hypoxia-inducible factor-1 alpha. Hearing Research 2010; 275:43-52. Impact factor: 2.848 (9.1%)
41. Chen HS, Ma HI, Sytwu HK, Wang HW, Chen CCV, Liu SC, Chen CH, Chen HK and Wang CH. Neural stem cells secrete
factors thatpromote auditory cell proliferation via a leukemia inhibitory factor signaling pathway. J Neurosci Res. 2010 Nov
15; 88(15):3308-3318. Impact Factor: 2.986 (45.2%). Impact factor 2.729 (56.2%)
42. Liang SJ, Hsu CS, Tzeng CR, Chen CH, Hsu MI. Clinical and biochemical presentation of polycystic ovary syndrome in
women between the ages of 20 and 40. Hum Reprod. 2011 Dec ;26(12):3443-3449. Impact factor 4.585(2.6%)
43. Lin HC, Chen CH, Su HY. Bier's Spots on Legs Associated with Deep Vein Thrombosis during Pregnancy. Taiwan J Obstet Gynecol. 2015 Feb;54(1):102-4 Impact factor: 1.261 (73.1%)
44. Wu HM, Tzeng CR, Chen CH, Chen PH. Pelvic endometriosis with peritoneal fluid reduces pregnancy rates in women
undergoing intrauterine insemination. Taiwan J Obstet Gynecol. 2013 Dec;52(4):512-515. Impact factor: 1.261 (73.1%)
45. Tzeng CR, Chang YC, Chang YC, Wang CW, Chen CH, Hsu MI. Cluster analysis of cardiovascular and metabolic risk
factors in women of reproductive age. Fertil Steril. 2014 May;101(5): 1404-1410. Impact factor: 4.295 (5.1%)
46. Wang MH, Chen CH, Wang CW, Hsu MI, Tzeng CR. A higher anti-Müllerian hormone level is associated with an
increased chance of pregnancy in patients undergoing controlled ovarian stimulation and intrauterine insemination. J Obstet Gynaecol. 2015 Jan;35(1):64-8. Impact factor: 0.604 (92.3%)

47. Lin HC, Chen CH, Su HY. Bier spots on legs associated with deep vein thrombosis during pregnancy. Taiwan J Obstet Gynecol. 2015 Feb;54(1):102-4.

48. Hsu MI, Wang CW, Chen CH, Tzeng CR. Impact of the number of retrieved oocytes on pregnancy outcome in in vitro fertilization. Taiwan J Obstet Gynecol. 2016 Dec;55(6):821-825.

 

49. Wang CY, Lai YJ, Hwang KS, Chen CH, Yu MH, Chen HT, Su HY. Successful treatment with granulocyte-colony stimulating factor for ritodrine-induced neutropenia in a twin pregnancy. Taiwan J Obstet Gynecol. 2016 Oct;55(5):738-740.

 

50. Chang-Chih Hsieh, Chi-Huang Chen*, Szu-Yu Shen, Chii-Ruey Tzeng. Babies born from three young infertile sisters with premature ovarian insufficiency caused by inherited Fragile X syndrome: an intergenerational report. Taiwan J Obstet Gynecol. 2017 Feb;56(1):112-113 (corresponding author)


 

51. Chen CW, Huang YL, Tzeng CR, Huang RL and *Chen CH (責任作者) Idiopathic Low Ovarian Reserve Is Associated with More Frequent Positive Thyroid Peroxidase Antibodies. Thyroid 2017 Sep;27(9):1194-1200. Impact factor: 7.557. 

52. Lee YX, Chen CW, CR Tzeng and *CH Chen (責任作者) Predicted a rare chromosome aberrations simultaneously with comprehensive chromosome screening in human preimplantation embryos for recurrent pregnancy loss. Journal of Assisted Reproduction and Genetics 2018 January 2018, Volume 35, Issue 1, pp 171–176 Impact factor: 2.788

53.Lai GL, Yeh CC, Yeh CY, Chen RY, Fu CL, Chen CH, Tzeng CR Decreased zinc and increased lead blood levels are associated with endometriosis in Asian Women. Reprod Toxicol. 2017 Sep 7;74:77-84 Impact factor: 2.341

54. *Chen CH (第一作者), Tzeng CR, Wang PH, Liu WM, Chang HY, Chen HH, Chen CH. Dual Triggering with GnRH Agonist plus hCG versus Triggering with hCG Alone for IVF/ICSI Outcome in GnRH Antagonist Cycles : a Systematic Review and Meta-Analysis. Archives of Gynecology and Obstetrics 2018 Mar 29. doi: 10.1007/s00404-018-4751-3 Impact factor: 2.236

55. An-Chieh Liu A, Chen CH, Liu WM, Chang CW. A rare Krukenberg tumor arising from a primary adenocarcinoma of the small intestine. Taiwan J Obstet Gynecol. 2018 Apr;57(2):319-322. doi: 10.1016/j.tjog.2018.02.025.

56. Chung MT, Tzeng CR, Chen CH, Chan C, Chang YE, Wu YH, Chen CH (責任作者). Live euploid birth and complete hydatid mole, followed by partial hydatid mole after ICSI. J Assist Reprod Genet. 2018 Jun 2. doi: 10.1007/s10815-018-1224-3. [Epub ahead of print]. Impact factor: 2.788

 

 

 

 

  

陳醫師研究主軸與成果

 

Research trunk JPG file